Abstract
A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.
MeSH terms
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Amino Acid Substitution
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Aminoglycosides*
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology*
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Binding Sites
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Candida / enzymology
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Cell Wall / enzymology
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Chitin Synthase / antagonists & inhibitors*
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Drug Design
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology
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Molecular Structure
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Protein Conformation
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Enzyme Inhibitors
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nikkomycin
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Chitin Synthase