Ligand-protein interactions in nuclear receptors of hormones

FEBS Lett. 2000 Jun 30;476(1-2):62-7. doi: 10.1016/s0014-5793(00)01672-0.

Abstract

Nuclear hormone receptors are transcription factors regulated by lipophilic ligands. These hormones bind to their nuclear receptor targets using an induced fit mechanism that triggers a large conformational change and generates the proper surface for the binding of protein coactivators. The molecular details of the various steps of this activation process or its inhibition by antagonists are now understood for several nuclear receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hormones / chemistry*
  • Hormones / metabolism*
  • Ligands
  • Models, Molecular
  • Protein Conformation
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Receptors, Retinoic Acid / chemistry*
  • Receptors, Retinoic Acid / metabolism*

Substances

  • Hormones
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Retinoic Acid