Integrin-collagen complex: a metal-glutamate handshake

Structure. 2000 Jun 15;8(6):R121-6. doi: 10.1016/s0969-2126(00)00153-2.

Abstract

The recently determined crystal structure of the complex between an integrin I domain and a synthetic collagen peptide shows a collagen triple-helix engaged in specific macromolecular recognition and binding. This structure confirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.

Publication types

  • Review

MeSH terms

  • Binding Sites
  • Collagen / chemistry*
  • Collagen / metabolism
  • Glutamic Acid / chemistry
  • Glutamic Acid / metabolism
  • Humans
  • In Vitro Techniques
  • Integrins / chemistry*
  • Integrins / metabolism
  • Macromolecular Substances
  • Metals / chemistry
  • Metals / metabolism
  • Models, Molecular
  • Protein Conformation
  • Signal Transduction

Substances

  • Integrins
  • Macromolecular Substances
  • Metals
  • Glutamic Acid
  • Collagen