Abstract
The recently determined crystal structure of the complex between an integrin I domain and a synthetic collagen peptide shows a collagen triple-helix engaged in specific macromolecular recognition and binding. This structure confirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.
MeSH terms
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Binding Sites
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Collagen / chemistry*
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Collagen / metabolism
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Glutamic Acid / chemistry
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Glutamic Acid / metabolism
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Humans
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In Vitro Techniques
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Integrins / chemistry*
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Integrins / metabolism
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Macromolecular Substances
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Metals / chemistry
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Metals / metabolism
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Models, Molecular
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Protein Conformation
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Signal Transduction
Substances
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Integrins
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Macromolecular Substances
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Metals
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Glutamic Acid
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Collagen