An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population

S D'Alfonso; L Nisticò; D Bocchio; R Bomprezzi; M G Marrosu; M R Murru; M Lai; L Massacesi; C Ballerini; A Repice; M Salvetti; C Montesperelli; G Ristori; M Trojano; M Liguori; D Gambi; A Quattrone; R Tosi; P Momigliano-Richiardi

An attempt of identifying MS-associated loci as a follow-up of a genomic linkage study in the Italian population

J Neurovirol. 2000 May:6 Suppl 2:S18-22.

Affiliation

¹ Chair of Human Genetics, Department of Medical Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.

PMID: 10871779

Abstract

Subsequent to a genomic linkage study on Sardinian and Continental Italian families, we considered the possibility that some of the tested microsatellite markers showed association to MS. Markers selected on the basis of the data obtained in the original set of 70 multiplex families were tested for MS association in an additional set of 154 simplex families. A limited set of markers were further tested on an additional set of 100 simplex families. The results indicate the presence of a putative MS gene in 19q13.13.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Chromosomes, Human, Pair 19*
Family Health*
Follow-Up Studies
Genetic Linkage*
HLA-DR Antigens / genetics
HLA-DRB1 Chains
Histocompatibility Testing
Humans
Italy
Microsatellite Repeats
Multiple Sclerosis / genetics*
Multiple Sclerosis / immunology

Substances

HLA-DR Antigens
HLA-DRB1 Chains