Abstract
Polymorphisms in the T-cell receptor genes can provide important information for the study of the immune response system, particularly for autoimmune diseases. This report characterizes a common T to C polymorphism in the promoter of the beta 2 constant chain of the T-cell receptor, which abolishes a recognition site for BglII restriction endonuclease.
Copyright 2000 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Alleles
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Bacterial Proteins*
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Deoxyribonucleases, Type II Site-Specific / metabolism
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Female
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Gene Frequency / genetics
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Genes, T-Cell Receptor beta / genetics*
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Genotype
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Humans
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Male
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Mutation / genetics
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Polymorphism, Genetic*
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Polymorphism, Restriction Fragment Length
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Promoter Regions, Genetic / genetics*
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White People / genetics
Substances
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Bacterial Proteins
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BglII endonuclease
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Deoxyribonucleases, Type II Site-Specific