A common T/C polymorphism in the promoter region of the beta T-cell receptor gene

Mol Cell Probes. 2000 Jun;14(3):195-7. doi: 10.1006/mcpr.2000.0301.

Abstract

Polymorphisms in the T-cell receptor genes can provide important information for the study of the immune response system, particularly for autoimmune diseases. This report characterizes a common T to C polymorphism in the promoter of the beta 2 constant chain of the T-cell receptor, which abolishes a recognition site for BglII restriction endonuclease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Bacterial Proteins*
  • Deoxyribonucleases, Type II Site-Specific / metabolism
  • Female
  • Gene Frequency / genetics
  • Genes, T-Cell Receptor beta / genetics*
  • Genotype
  • Humans
  • Male
  • Mutation / genetics
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Promoter Regions, Genetic / genetics*
  • White People / genetics

Substances

  • Bacterial Proteins
  • BglII endonuclease
  • Deoxyribonucleases, Type II Site-Specific