Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance

Adv Exp Med Biol. 2000:477:187-95. doi: 10.1007/0-306-46826-3_21.
No abstract available

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Binding, Competitive
  • CHO Cells
  • Cricetinae
  • Cyclic AMP / metabolism
  • Diabetes Mellitus, Type 2
  • Dipeptidyl Peptidase 4 / metabolism*
  • Drug Design
  • Gastric Inhibitory Polypeptide / chemistry
  • Gastric Inhibitory Polypeptide / metabolism*
  • Humans
  • Hydrolysis
  • Peptide Fragments / chemical synthesis
  • Peptide Fragments / metabolism
  • Peptide Fragments / pharmacology*
  • Rats
  • Receptors, Gastrointestinal Hormone / drug effects
  • Receptors, Gastrointestinal Hormone / genetics
  • Receptors, Gastrointestinal Hormone / metabolism
  • Recombinant Fusion Proteins / metabolism
  • Second Messenger Systems / drug effects
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Substances

  • Peptide Fragments
  • Receptors, Gastrointestinal Hormone
  • Recombinant Fusion Proteins
  • Gastric Inhibitory Polypeptide
  • gastric inhibitory polypeptide receptor
  • Cyclic AMP
  • Dipeptidyl Peptidase 4