Hematological manifestations of congenital cytomegalovirus infection

Indian J Pediatr. 1995 Jul-Aug;62(4):473-7. doi: 10.1007/BF02755070.

Abstract

Nine infants suffering from congenital cytomegalovirus infection were studied for clinical features with special reference to hematological manifestations. The mean age of appearance of first clinical symptom of disease was 14 days and mean age at presentation was 58 days. Significant pallor, thrombocytopenia and evidence of hemolysis were present in 8 (89%), 4 (44%) and 4 (44%) patients respectively out of three bone marrow examination performed, paucity of erythroid and megakaryocytic cells were seen in two. The other clinical features included hepatomegaly in a (100%) splenomegaly in 6 (66%) each, petachial rash in 5 (55%), Hepatitis in 4 (44%) optic atrophy and corneal opacities in one patient each. Two patients died. Remaining patients showed symptomatic improvement without specific therapy.

Publication types

  • Clinical Trial

MeSH terms

  • Cytomegalovirus Infections / congenital*
  • Cytomegalovirus Infections / diagnosis*
  • Cytomegalovirus Infections / mortality
  • Female
  • Hematologic Diseases / mortality
  • Hematologic Diseases / physiopathology*
  • Hematologic Diseases / virology*
  • Humans
  • India
  • Infant, Newborn
  • Male
  • Prognosis
  • Severity of Illness Index
  • Survival Analysis