Specialized transcription factories within mammalian nuclei

A Pombo; E Jones; F J Iborra; H Kimura; K Sugaya; P R Cook; D A Jackson

Specialized transcription factories within mammalian nuclei

Crit Rev Eukaryot Gene Expr. 2000;10(1):21-9.

Authors

A Pombo¹, E Jones, F J Iborra, H Kimura, K Sugaya, P R Cook, D A Jackson

Affiliation

¹ Sir William Dunn School of Pathology, University of Oxford, UK.

PMID: 10813391

Abstract

Recent evidence suggests that active RNA polymerases are concentrated in discrete 'factories' where they work together on many different templates. The evidence that such factories specialize in the transcription of particular groups of genes is reviewed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Nucleolus / metabolism
Cell Nucleus / metabolism*
DNA-Directed RNA Polymerases / metabolism
HeLa Cells
Humans
Transcription Factors / metabolism
Transcription, Genetic / physiology*

Substances

Transcription Factors
DNA-Directed RNA Polymerases