BgK anemone toxin inhibits outward K(+) currents in snail neurons

Brain Res. 2000 May 12;864(2):312-4. doi: 10.1016/s0006-8993(00)02131-4.

Abstract

We studied the effects of BgK toxin on outward K(+) currents in isolated neurons of the snail Helix aspersa, using the whole cell patch clamp technique. BgK partially and reversibly blocked K(+) currents in the 1 pM to 100 nM concentration range (n=53). The dose-response curve for BgK current inhibition had a maximum blocking effect at 100 nM. Our results indicate that BgK is a potent, apparently non-selective, K(+) channel blocker in molluscan neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cnidarian Venoms / pharmacology*
  • Dose-Response Relationship, Drug
  • Helix, Snails
  • Membrane Potentials / drug effects
  • Neurons / chemistry*
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Potassium / metabolism
  • Potassium Channel Blockers*
  • Potassium Channels / physiology
  • Sea Anemones

Substances

  • Cnidarian Venoms
  • Potassium Channel Blockers
  • Potassium Channels
  • toxin BgK
  • Potassium