A cytotoxic sesquiterpene caffeate from the liverwort Bazzanianovae-zelandiae

E J Burgess; L Larsen; N B Perry

doi:10.1021/np990492x

A cytotoxic sesquiterpene caffeate from the liverwort Bazzanianovae-zelandiae

J Nat Prod. 2000 Apr;63(4):537-9. doi: 10.1021/np990492x.

Authors

E J Burgess¹, L Larsen, N B Perry

Affiliation

¹ Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Limited, Department of Chemistry, University of Otago, Dunedin, New Zealand.

PMID: 10785435
DOI: 10.1021/np990492x

Abstract

Extracts of the liverwort Bazzania novae-zelandiae were cytotoxic, with selective activity against human tumor cell lines. Bioactivity-directed isolation work showed that the new compound naviculyl caffeate (1) was the main cytotoxin. This structure was confirmed by synthesis from the co-occurring sesquiterpene naviculol (2).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Caffeic Acids / chemistry
Caffeic Acids / isolation & purification*
Caffeic Acids / pharmacology
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
New Zealand
Plants, Medicinal / chemistry*
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Caffeic Acids
naviculyl caffeate