Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure

T Fichert; A Regelin; U Massing

doi:10.1016/s0960-894x(00)00099-8

Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure

Bioorg Med Chem Lett. 2000 Apr 17;10(8):787-91. doi: 10.1016/s0960-894x(00)00099-8.

Authors

T Fichert¹, A Regelin, U Massing

Affiliation

¹ Tumor Biology Center, Department of Clinical Research, Freiburg, Germany.

PMID: 10782687
DOI: 10.1016/s0960-894x(00)00099-8

Abstract

This report describes the synthesis and the transfection properties of novel monocationic non-toxic lipids. We have carried out structural variations in all three units of the transfection lipid, the lipid anchor, the spacer moiety and the positively charged head group. Our results lead to the conclusion that systematic modification of structural subunits is a promising way to enhance the transfection efficiency.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
COS Cells
Lipids / chemical synthesis
Lipids / chemistry*
Molecular Structure
Transfection*

Substances

Lipids