The abasic site as a target for generation of locally multiply damaged sites

Bioorg Med Chem Lett. 2000 Apr 17;10(8):763-6. doi: 10.1016/s0960-894x(00)00081-0.

Abstract

Abasic sites in DNA have been specifically targeted by synthetic compounds able to cleave DNA at abasic sites and to induce photodamages in the vicinity of the lesion. The synthesis and the photoactivity of the drugs on abasic sites containing DNA and oligonucleotides are reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology
  • DNA / chemistry
  • DNA / drug effects*
  • DNA / radiation effects
  • DNA Damage*
  • Photochemistry

Substances

  • Antineoplastic Agents
  • DNA