4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB

C J Andres; J J Bronson; S V D'Andrea; M S Deshpande; P J Falk; K A Grant-Young; W E Harte; H T Ho; P F Misco; J G Robertson; D Stock; Y Sun; A W Walsh

doi:10.1016/s0960-894x(00)00073-1

4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB

Bioorg Med Chem Lett. 2000 Apr 17;10(8):715-7. doi: 10.1016/s0960-894x(00)00073-1.

Authors

C J Andres¹, J J Bronson, S V D'Andrea, M S Deshpande, P J Falk, K A Grant-Young, W E Harte, H T Ho, P F Misco, J G Robertson, D Stock, Y Sun, A W Walsh

Affiliation

¹ Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.

PMID: 10782671
DOI: 10.1016/s0960-894x(00)00073-1

Abstract

4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.

MeSH terms

Bacteria / enzymology*
Carbohydrate Dehydrogenases / antagonists & inhibitors*
Enzyme Inhibitors / pharmacology*
Thiazoles / pharmacology*

Substances

Enzyme Inhibitors
Thiazoles
Carbohydrate Dehydrogenases
UDP-N-acetylmuramate dehydrogenase