Regulation of T cell function by NK cell receptors for classical MHC class I molecules

Curr Opin Immunol. 2000 Jun;12(3):295-300. doi: 10.1016/s0952-7915(00)00090-x.

Abstract

Inhibitory receptors for MHC class I molecules were initially characterised on NK cells. Human and mouse NK cell receptors (NKRs) are also expressed on T cells, predominantly on a subset of memory-phenotype CD8(+) T cells. This review focuses on the precise determination of interactions between NKRs and MHC class I, as well as on the unexpected in vivo function of NKRs on T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, CD*
  • Antigens, Ly*
  • CD8-Positive T-Lymphocytes
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Immunologic Memory
  • Killer Cells, Natural*
  • Lectins, C-Type
  • Leukocyte Immunoglobulin-like Receptor B1
  • Membrane Glycoproteins / metabolism
  • Mice
  • Receptors, Immunologic / metabolism*
  • Receptors, KIR
  • Receptors, NK Cell Lectin-Like
  • T-Lymphocytes / immunology*

Substances

  • Antigens, CD
  • Antigens, Ly
  • Histocompatibility Antigens Class I
  • LILRB1 protein, human
  • Lectins, C-Type
  • Leukocyte Immunoglobulin-like Receptor B1
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • Receptors, KIR
  • Receptors, NK Cell Lectin-Like