Synthesis and structure-activity relationships of novel nikkomycin analogs: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase

J Uda; K Obi; K Iwase; O Sugimoto; H Ebisu; A Matsuda

doi:10.1093/nass/42.1.13

Synthesis and structure-activity relationships of novel nikkomycin analogs: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase

Nucleic Acids Symp Ser. 1999:(42):13-4. doi: 10.1093/nass/42.1.13.

Authors

J Uda¹, K Obi, K Iwase, O Sugimoto, H Ebisu, A Matsuda

Affiliation

¹ Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Tochigi-ken, Japan.

PMID: 10780355
DOI: 10.1093/nass/42.1.13

Abstract

A series of novel nikkomycin analogs, which inhibited chitin synthase, the fungal cell wall biosynthesis enzyme, has been synthesized and evaluated their inhibitory activities.

MeSH terms

Aminoglycosides*
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Chitin Synthase / antagonists & inhibitors*
Drug Design
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Models, Molecular
Structure-Activity Relationship
Uridine Diphosphate N-Acetylglucosamine / chemistry

Substances

Aminoglycosides
Anti-Bacterial Agents
Antifungal Agents
Enzyme Inhibitors
Uridine Diphosphate N-Acetylglucosamine
nikkomycin
Chitin Synthase