Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue

A Vidal; T Durand; J P Vidal; J C Rossi; S Ravasi; S Zarini; A Sala

doi:10.1016/s0960-894x(00)00076-7

Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue

Bioorg Med Chem Lett. 2000 Apr 3;10(7):665-8. doi: 10.1016/s0960-894x(00)00076-7.

Authors

A Vidal¹, T Durand, J P Vidal, J C Rossi, S Ravasi, S Zarini, A Sala

Affiliation

¹ Laboratoire de Chimie Biomoléculaire et Interactions Biologiques associé au C.N.R.S., Université Montpellier 1, Faculté de Pharmacie, France.

PMID: 10762049
DOI: 10.1016/s0960-894x(00)00076-7

Abstract

New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Platelets / enzymology
Blood Platelets / metabolism
Glutathione Transferase / metabolism
Humans
Leukotriene A4 / analogs & derivatives*
Leukotriene A4 / chemical synthesis
Leukotriene A4 / metabolism
Leukotriene C4 / analogs & derivatives*
Leukotriene C4 / chemical synthesis
Leukotriene C4 / chemistry
Organotin Compounds / chemical synthesis*
Organotin Compounds / metabolism

Substances

19-((2-azido-5-iodo)benzoyloxy)leukotriene A(4)
19-((2-azido-5-trimethylstannyl)benzoyloxy)leukotriene A(4)
Leukotriene A4
Organotin Compounds
Leukotriene C4
Glutathione Transferase
leukotriene-C4 synthase