Abstract
Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Brain / physiology
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Cyclooxygenase 1
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Cyclooxygenase 2
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Digestive System Physiological Phenomena
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Female
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Genitalia, Female / physiology
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Humans
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Isoenzymes / metabolism
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Isoenzymes / physiology*
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Kidney / physiology
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Membrane Proteins
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Prostaglandin-Endoperoxide Synthases / metabolism
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Prostaglandin-Endoperoxide Synthases / physiology*
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Thrombosis / physiopathology
Substances
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Isoenzymes
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Membrane Proteins
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Cyclooxygenase 1
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Cyclooxygenase 2
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PTGS1 protein, human
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases