Nasimaluns A and B: neo-clerodane diterpenoids from barringtonia racemosa

J Nat Prod. 2000 Mar;63(3):410-1. doi: 10.1021/np990488l.

Abstract

An ethanolic extract of the roots of Barringtonia racemosa afforded two novel neo-clerodane-type diterpenoids, methyl-15, 16-epoxy-12-oxo-3,13(16),14-neo-clerodatrien-18, 19-olide-17-carboxylate (nasimalun A, 1) and dimethyl-15,16-epoxy-3, 13(16),14-neo-clerodatrien-17,18-dicarboxylate (17-carboxymethylhardwickiic acid methyl ester, nasimalun B, 2) by NMR and MS analyses and by comparison of their spectral data with related compunds. The relative stereochemistry of the asymmetric centers in 1 and 2 was determined by selective 1D NOESY experiments.

MeSH terms

  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Spectrum Analysis

Substances

  • Diterpenes
  • nasimalun A
  • nasimalun B