7-Epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from lake Kinneret, Israel

R Banker; B Teltsch; A Sukenik; S Carmeli

doi:10.1021/np990498m

7-Epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from lake Kinneret, Israel

J Nat Prod. 2000 Mar;63(3):387-9. doi: 10.1021/np990498m.

Authors

R Banker¹, B Teltsch, A Sukenik, S Carmeli

Affiliation

¹ School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.

PMID: 10757726
DOI: 10.1021/np990498m

Abstract

A toxic minor metabolite, 7-epicylindrospermopsin (1), was isolated from a culture of the cyanobacterium Aphanizomenon ovalisporum isolated from Lake Kinneret in Israel. Homonuclear and inverse-heteronuclear 2D NMR techniques, as well as HRMS and comparison of the NMR data with model compounds, enabled the structure determination of the new compound. Four polymethoxy-1-alkenes, 3-6, were isolated from the lipophilic extract of the cyanobacterium as well.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids
Bacterial Toxins
Cyanobacteria / metabolism*
Cyanobacteria Toxins
Molecular Structure
Spectrum Analysis
Uracil / analogs & derivatives*
Uracil / chemistry
Uracil / isolation & purification

Substances

Alkaloids
Bacterial Toxins
Cyanobacteria Toxins
cylindrospermopsin
Uracil