Abstract
Matrix-metalloproteinases (MMPs) are associated with invasive and metastatic behavior of several human malignant tumors. We have determined MMP-2 and MMP-9 and tissue inhibitors of MMPs (TIMP-1 and TIMP-2) in blood plasma and in renal tissue samples of patients with renal cell carcinoma (RCC) from cancerous and non-cancerous parts of the same kidney. In tumor tissue, MMP-9 and TIMP-1 were significantly higher than in normal counterparts. MMP-2 was not different between tumor tissue and normal counterparts. TIMP-2 values could not be measured. In plasma, MMP-9 concentrations were significantly higher in RCC patients than in healthy controls, MMP-2 and TIMP-2 concentrations were higher in healthy controls and TIMP-1 concentrations were not different.
Copyright 2000 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Carcinoma, Renal Cell / blood
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Carcinoma, Renal Cell / metabolism*
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Carcinoma, Renal Cell / pathology
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Female
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Humans
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Kidney Neoplasms / blood
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Kidney Neoplasms / metabolism*
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Kidney Neoplasms / pathology
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Male
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Matrix Metalloproteinase 2 / blood
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Matrix Metalloproteinase 2 / metabolism
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Matrix Metalloproteinase 9 / blood
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Matrix Metalloproteinase 9 / metabolism
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Matrix Metalloproteinases / blood
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Matrix Metalloproteinases / metabolism*
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Middle Aged
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Tissue Inhibitor of Metalloproteinase-1 / blood
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Tissue Inhibitor of Metalloproteinase-1 / metabolism
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Tissue Inhibitor of Metalloproteinase-2 / blood
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Tissue Inhibitor of Metalloproteinase-2 / metabolism
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Tissue Inhibitor of Metalloproteinases / blood
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Tissue Inhibitor of Metalloproteinases / metabolism*
Substances
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Tissue Inhibitor of Metalloproteinase-1
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Tissue Inhibitor of Metalloproteinases
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Tissue Inhibitor of Metalloproteinase-2
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Matrix Metalloproteinases
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Matrix Metalloproteinase 2
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Matrix Metalloproteinase 9