Abstract
Easily accessible Ac-(Z)-delta Phe-NHMe was photoisomerized to so far unknown Ac-(E)-delta Phe-NHMe. Some parameters of the process leading to a diastereomeric mixture of ratio 90(Z):10(E) have been tested and the photoisomerization has been carried out on a preparative milligram scale. The isomers were separated via crystallization followed by preparative HPLC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Crystallization
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Isomerism
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Magnetic Resonance Spectroscopy
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Peptides / chemical synthesis*
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Phenylalanine / analogs & derivatives*
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Phenylalanine / chemical synthesis
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Phenylalanine / chemistry
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Phenylalanine / radiation effects
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Photochemistry
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Stereoisomerism
Substances
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Peptides
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acetyl-alpha,beta-dehydrophenylalanine methylamide
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Phenylalanine