The abnormal changes of peripheral blood neutrophils in 13 patients with hepatitis B were observed under electron microscope. The morphological and structural changes of neutrophils included irregularity of shape, a large number of pseudopodia and phagocytic vacuoles, less electron dense granules, increased nuclear holes and vacuoles, etc. The present study provides the ultrastructural evidence of impaired neutrophil morphology and functions in such patients.