A new benzoangelicin with strong photobiological activity

Bioorg Med Chem Lett. 2000 Jan 17;10(2):135-7. doi: 10.1016/s0960-894x(99)00640-x.

Abstract

Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4-6 exhibited cutaneous phototoxicity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Benzofurans / chemical synthesis*
  • Benzofurans / pharmacology
  • Coumarins / chemical synthesis*
  • Coumarins / chemistry
  • Coumarins / pharmacology
  • DNA / metabolism
  • HL-60 Cells / drug effects
  • HeLa Cells / drug effects
  • Humans
  • Kinetics
  • Methoxsalen / pharmacology
  • Molecular Structure
  • Photosensitizing Agents / chemical synthesis*
  • Photosensitizing Agents / pharmacology
  • Ultraviolet Rays

Substances

  • 5-(N,N-dimethylaminopropoxy)-4-methylbenzofuro(1,2-h)benzopyran-2-one
  • Antineoplastic Agents
  • Benzofurans
  • Coumarins
  • Photosensitizing Agents
  • DNA
  • Methoxsalen