Abstract
Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4-6 exhibited cutaneous phototoxicity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Benzofurans / chemical synthesis*
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Benzofurans / pharmacology
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Coumarins / chemical synthesis*
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Coumarins / chemistry
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Coumarins / pharmacology
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DNA / metabolism
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HL-60 Cells / drug effects
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HeLa Cells / drug effects
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Humans
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Kinetics
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Methoxsalen / pharmacology
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Molecular Structure
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Photosensitizing Agents / chemical synthesis*
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Photosensitizing Agents / pharmacology
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Ultraviolet Rays
Substances
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5-(N,N-dimethylaminopropoxy)-4-methylbenzofuro(1,2-h)benzopyran-2-one
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Antineoplastic Agents
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Benzofurans
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Coumarins
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Photosensitizing Agents
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DNA
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Methoxsalen