Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland

K Ofuji; M Satake; T McMahon; J Silke; K J James; H Naoki; Y Oshima; T Yasumoto

doi:10.1002/(sici)1522-7189(199905/06)7:3<99::aid-nt46>3.0.co;2-l

Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland

Nat Toxins. 1999;7(3):99-102. doi: 10.1002/(sici)1522-7189(199905/06)7:3<99::aid-nt46>3.0.co;2-l.

Authors

K Ofuji¹, M Satake, T McMahon, J Silke, K J James, H Naoki, Y Oshima, T Yasumoto

Affiliation

¹ Department of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.

PMID: 10647511
DOI: 10.1002/(sici)1522-7189(199905/06)7:3<99::aid-nt46>3.0.co;2-l

Abstract

Two new analogs of azaspiracid, azaspiracid-2 and azaspiracid-3, were isolated from mussels collected at Arranmore Island, Ireland in 1997 as additional causes of human intoxication. Their structures were determined to be 8-methylazaspiracid and 22-demethylazaspiracid, respectively by NMR and negative ion FAB CID MS/MS experiments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bivalvia / chemistry*
Foodborne Diseases / etiology*
Humans
Magnetic Resonance Spectroscopy
Male
Marine Toxins / analysis*
Marine Toxins / chemistry
Mass Spectrometry
Mice

Substances

Marine Toxins