Megistosarcimine and megistosarconine, two alkaloids from Sarcomelicope megistophylla

N Fokialakis; S Mitaku; E Mikros; A L Skaltsounis; F Tillequin; T Sevenet

doi:10.1016/s0031-9422(99)00323-4

Megistosarcimine and megistosarconine, two alkaloids from Sarcomelicope megistophylla

Phytochemistry. 1999 Dec;52(8):1745-8. doi: 10.1016/s0031-9422(99)00323-4.

Authors

N Fokialakis¹, S Mitaku, E Mikros, A L Skaltsounis, F Tillequin, T Sevenet

Affiliation

¹ Laboratoire de Pharmacognosie de l'Université René Descartes, URA au CNRS No 1310, Faculté de Pharmacie, Paris, France.

PMID: 10647223
DOI: 10.1016/s0031-9422(99)00323-4

Abstract

Two new alkaloids, megistosarcimine and megistosarconine, were isolated from the aerial parts of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of their spectral data and molecular modeling.

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / toxicity
Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / toxicity
Cell Survival / drug effects
Leukemia L1210
Magnetic Resonance Spectroscopy
Mice
Models, Molecular
Molecular Conformation
Trees*
Tumor Cells, Cultured

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
megistosarcimine
megistosarconine