Abstract
The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 microg/ml).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival
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Cholestanones / chemistry*
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Cholestanones / isolation & purification*
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Cholestanones / toxicity
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Cnidaria / chemistry*
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Cytotoxins / chemistry*
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Cytotoxins / isolation & purification
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Humans
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Spain
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Steroids / chemistry*
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Steroids / isolation & purification*
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Steroids / toxicity
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Tumor Cells, Cultured
Substances
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16,20-dihydroxycholestan-3-one
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20-hydroxycholest-1-en-3,16-dione
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20-hydroxycholestane-3,16-dione
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Cholestanones
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Cytotoxins
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Steroids