Bacteremic pneumonia caused by a single clone of Streptococcus pneumoniae with different optochin susceptibilities

J Clin Microbiol. 2000 Jan;38(1):458-9. doi: 10.1128/JCM.38.1.458-459.2000.

Abstract

Two isolates of Streptococcus pneumoniae having different optochin susceptibilities were recovered from a blood sample of a 2-year-old boy with community-acquired pneumonia. The two isolates were documented to belong to a single clone on the basis of the isolates' identical serotype (23F), antibiograms by the E-test, random amplified polymorphic DNA patterns generated by arbitrarily primed PCR, pulsed-field gel electrophoresis, and restriction fragment length polymorphism of the penicillin-binding protein genes pbp2b and pbp2x.

Publication types

  • Case Reports

MeSH terms

  • Bacteremia / drug therapy
  • Bacteremia / microbiology*
  • Bacterial Typing Techniques
  • Cefazolin / therapeutic use
  • Cephalexin / therapeutic use
  • Child, Preschool
  • Clone Cells
  • Community-Acquired Infections
  • Electrophoresis, Gel, Pulsed-Field
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Pneumonia, Pneumococcal / drug therapy
  • Pneumonia, Pneumococcal / microbiology*
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Quinine / analogs & derivatives*
  • Quinine / pharmacology
  • Random Amplified Polymorphic DNA Technique
  • Serotyping
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / drug effects*

Substances

  • ethylhydrocupreine
  • Quinine
  • Cefazolin
  • Cephalexin