Abstract
Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6-fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59-72%.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Nucleosides / chemical synthesis*
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Organosilicon Compounds / chemistry*
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Purines / chemical synthesis*
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Purines / chemistry*
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Quaternary Ammonium Compounds / chemistry*
Substances
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Nucleosides
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Organosilicon Compounds
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Purines
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Quaternary Ammonium Compounds
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tetrabutylammonium triphenyldifluorosilicate
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6-fluoropurine
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6-chloropurine