Vinylamycin, a new depsipeptide antibiotic, from Streptomyces sp

J Antibiot (Tokyo). 1999 Oct;52(10):873-9. doi: 10.7164/antibiotics.52.873.

Abstract

A new depsipeptide antibiotic, vinylamycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MI982-63F1, was identified as a member of Streptomyces. Vinylamycin was isolated from the culture broth by extraction with EtOAc and purified by crystallization from EtOAc. The structure of vinylamycin was determined by spectroscopic analysis and degradation studies. Vinylamycin showed antimicrobial activities against Gram-positive bacteria including MRSA.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins*
  • Cells, Cultured
  • Depsipeptides*
  • Fermentation
  • Gram-Positive Bacteria / drug effects*
  • Injections, Intraperitoneal
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Peptides*
  • Streptomyces

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Depsipeptides
  • Peptides
  • vinylamycin