Amantadine-induced peripheral neuropathy

Neurology. 1999 Nov 10;53(8):1862-5. doi: 10.1212/wnl.53.8.1862.

Abstract

We report a 48-year-old woman with a 17-year history of PD who developed a peripheral sensory-motor neuropathy secondary to chronic administration (8 years) of amantadine. Discontinuation of amantadine resulted in resolution of trophic skin ulcers, paresthesias, and distal weakness. Amantadine may be hazardous to patients with severe and chronic livedo reticularis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amantadine / adverse effects*
  • Antiparkinson Agents / adverse effects*
  • Chronic Disease
  • Female
  • Humans
  • Leg
  • Middle Aged
  • Muscle Weakness / chemically induced
  • Paresthesia / chemically induced
  • Parkinson Disease / complications
  • Parkinson Disease / drug therapy
  • Peripheral Nervous System Diseases / chemically induced*
  • Skin Diseases, Vascular / complications
  • Skin Ulcer / chemically induced

Substances

  • Antiparkinson Agents
  • Amantadine