Obstetrical complications and childhood-onset schizophrenia

Am J Psychiatry. 1999 Oct;156(10):1650-2. doi: 10.1176/ajp.156.10.1650.

Abstract

Objective: Increased obstetrical complications have been reported in individuals with adult-onset schizophrenia, with several studies finding an association between such complications and an earlier age at onset. Consequently, obstetrical records were examined for individuals with childhood-onset schizophrenia to determine if birth complications were more prevalent.

Method: The birth records of 36 patients with childhood-onset schizophrenia and 35 sibling comparison subjects were rated for birth complications by two psychiatrists who were unaware of group membership.

Results: There were no significant differences between the groups in rates of obstetrical complications. Patients with such complications did not have a relatively earlier age at onset of schizophrenia.

Conclusions: A very early age at onset of schizophrenia is probably not due to birth complications.

Publication types

  • Comparative Study

MeSH terms

  • Age of Onset
  • Comorbidity
  • Family*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Male
  • Medical Records
  • Obstetric Labor Complications / epidemiology*
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Schizophrenia / diagnosis
  • Schizophrenia / epidemiology*
  • Schizophrenia / genetics
  • Sex Factors