[The genotype-based haplotype relative risk and transmission disequilibrium test analyses of familial febrile convulsions]

Y Qi; X Wu; Z Guo; J Zhang; H Pan; M Li; X Bao; J Peng; L Zou; Q Lin

[The genotype-based haplotype relative risk and transmission disequilibrium test analyses of familial febrile convulsions]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Oct;16(5):296-8.

[Article in Chinese]

Authors

Y Qi¹, X Wu, Z Guo, J Zhang, H Pan, M Li, X Bao, J Peng, L Zou, Q Lin

Affiliation

¹ Department of Pediatrics, The First Teaching Hospital of Beijing Medical University, Beijing, 100034 P. R. China. pedlab@public.east.cn.net

PMID: 10514535

Abstract

Objective: To confirm the linkage of familial febrile convulsions to the short arm of chromosome 6(6p) or the long arm of chromosome 8(8q).

Methods: The authors finished genotyping of Pst I locus on the coding region of heat shock protein (HSP) 70, 5'untranslated region of HSP70-1, 3' untranslated region of HSP70-2, D8S84 and D8S85. The data were processed by the genotype-based haplotype relative risk(GHRR) and transmission disequilibrium test(TDT) methods in PPAP.

Results: Some signs of association and disequilibrium between D8S85 and FC were shown by GHRR and TDT.

Conclusion: A suspect linkage of familial febrile convulsions to the long arm of chromosome 8 has been proposed.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 8
Genotype
Haplotypes*
Humans
Linkage Disequilibrium
Risk
Seizures, Febrile / genetics*