Replacement of internal protein genes, with the exception of the matrix, in equine 1 viruses by equine 2 influenza virus genes during evolution in nature

J Vet Med Sci. 1999 Aug;61(8):987-9. doi: 10.1292/jvms.61.987.

Abstract

To establish the evolutionary association between the equine 1 H7 HA and M genes, phylogenetic analyses of the six internal gene segments of equine 1 influenza viruses (H7N7 subtype) were performed using partial nucleotide sequences. The results demonstrated that five internal genes (PBI, PB2, PA, NP and NS) of equine 1 viruses isolated after 1964 were replaced by those of equine 2 H3N8 viruses. However, the M gene was maintained during the evolution of these equine 1 viruses. These findings suggest a functional association between equine H7 HA and M gene products, most likely M2 protein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Horse Diseases / genetics
  • Horse Diseases / virology*
  • Horses
  • Hydrogen-Ion Concentration
  • Influenza A virus / genetics*
  • Orthomyxoviridae Infections / genetics
  • Orthomyxoviridae Infections / veterinary*
  • Phylogeny
  • Protein Conformation
  • Viral Proteins / genetics*

Substances

  • Viral Proteins