Abstract
The antiproliferative effects of squamocin, one of the easiest annonaceous acetogenins to obtain, were studied in the parental (MCF7-S) and the multidrug resistant (MCF7-R) human breast adenocarcinoma cell lines. Squamocin inhibited proliferation of both cell lines identically, by blocking the cell cycle in the G1-phase. This inhibition was reversible in the long term. Squamocin decreased the ATP pool in both MCF7 cell lines, but did not seem to induce apoptosis. Cytotoxic activity of adriamycin was not restored in MCF7-R Pgp expressing cells by squamocin addition.
MeSH terms
-
Adenocarcinoma / drug therapy*
-
Adenocarcinoma / pathology
-
Antibiotics, Antineoplastic / pharmacology
-
Antibiotics, Antineoplastic / therapeutic use
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Antineoplastic Agents, Phytogenic / therapeutic use
-
Apoptosis / drug effects
-
Breast Neoplasms / drug therapy*
-
Breast Neoplasms / pathology
-
Cell Division / drug effects
-
Dose-Response Relationship, Drug
-
Doxorubicin / pharmacology
-
Doxorubicin / therapeutic use
-
Drug Resistance, Multiple
-
Female
-
Furans / pharmacology*
-
Furans / therapeutic use
-
G1 Phase / drug effects
-
Humans
-
Lactones / pharmacology*
-
Lactones / therapeutic use
-
Tumor Cells, Cultured
Substances
-
Antibiotics, Antineoplastic
-
Antineoplastic Agents, Phytogenic
-
Furans
-
Lactones
-
squamocin
-
Doxorubicin