Objective: In order to explore the changes of MDA, SOD in each period of diabetic nephrosis patients, the contents of MDA and SOD from 40 cases of NIDDM nephrosis patients in various stages and 15 cases of normal persons (control group) were measured.
Methods: By using method of sulpho-barbiamino acid to determine the concentration of serum MDA (the reagents are provided by Juli Biomedical Engineering Institute of Nanjing). By using method of radioimmunization to determine the concentration of SOD (The reagents are provided by Huaqing Biological Technic Institute of Beijing), blood sugar, T-cho, TG, Bun, Ccr, UAE, etc. in serum were simutaneouslly determined. By adopting statistical method to analyse the mean difference in each groups and the interrelation of each data.
Results: The results show that the content of MDA in each groups exceeds normal control group and the content of MDA of the group of diabetic kidney failure (DKF) exceeds group of diabetic kidney early stage (DKE) obviously (P < 0.01). Only trace of MDA and SOD can be detected in the liquid of peritoneal dialysis in group of DKF. The content of SOD in each groups exceeds normal control group without exception and the content of SOD in group of DKF exceeds that of the group of diabetic kidney function injury stage obviously (P < 0.01).
Conclusion: Our results suggest that content of SOD might have some clinical value for the diagnosis and prognosis in NIDDM nephrosis and situation of kidney function injury.