Abstract
This study describes the synthesis and some pharmacological properties of three new analogs of arginine vasopressin (AVP) substituted in position 3 with (R)-alpha-hydroxymethylphenylalanine ([R]-HmPhe). All new peptides were tested for vasopressor and antidiuretic as well as uterotonic activity. None of the 3 analogs showed any pressor activity and their uterotonic activity was negligible. Only analog [Mpa1,(R)-HmPhe3]AVP exhibited significant antidiuretic activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arginine Vasopressin / analogs & derivatives*
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Arginine Vasopressin / chemical synthesis
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Arginine Vasopressin / chemistry
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Arginine Vasopressin / pharmacology
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Deamino Arginine Vasopressin / pharmacology
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Diuresis / drug effects
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Female
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Oxytocin / pharmacology
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Phenylalanine / analogs & derivatives*
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Phenylalanine / chemistry
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Rats
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Rats, Wistar
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Structure-Activity Relationship
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Uterine Contraction / drug effects
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Vasoconstriction / drug effects
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Vasopressins / pharmacology
Substances
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Vasopressins
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Arginine Vasopressin
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4-hydroxymethylphenylalanine
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Phenylalanine
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Oxytocin
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Deamino Arginine Vasopressin