The objective of this study was to develop a comprehensive picture of the concerns and needs of persons living with HIV/AIDS who are interested in returning to work. To collect information in this new area, a series of focus groups was conducted with a random sample of clients from AIDS Project Los Angeles who were currently unemployed and expressed a desire to return to work. The results indicate a range of concerns among individuals with HIV/AIDS about returning to work, such as a loss of or change in medical benefits, the need for flexibility in employment to address ongoing medical needs, concerns regarding disclosure of their HIV/AIDS status, the possibility of job related discrimination, and the need to address the practical aspects of reentering the labor market after a prolonged absence. The findings suggest a series of action steps for AIDS service organizations and others to address the needs of persons with HIV/AIDS in this new area.