Malignancy-simulating change in parotid gland oncocytoma following fine needle aspiration. Report of 3 cases

Pathol Res Pract. 1999;195(6):399-405. doi: 10.1016/S0344-0338(99)80013-2.

Abstract

We report here there cases of benign parotid gland oncocytoma with pseudomalignant change that mimic acinic cell carcinoma. All patients underwent fine-needle aspiration biopsy of the tumor 62, 725 and 33 days before surgical excision. In histologic sections, there were clusters of pigmented cells with PAS-positive foamy to finely granular cytoplasm similar to those seen in salivary gland acinic cell carcinomas. This report provides another, previously undescribed, example of a diagnostic pitfall that may be observed in histologic tissue specimens removed after FNA of oncocytic tumors.

MeSH terms

  • Adenoma, Oxyphilic / metabolism
  • Adenoma, Oxyphilic / pathology*
  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism
  • Biopsy, Needle
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Mitochondria / metabolism
  • Parotid Neoplasms / metabolism
  • Parotid Neoplasms / pathology*

Substances

  • Biomarkers, Tumor