Abstract
Six new triterpenoid saponins, maelaxins A-F (1-6), were isolated from a n-BuOH extract of the leaves of Maesa laxiflora. They possess 22-O-angeloyl-camelliagenin A, 16-O-acetyl, 22-O-angeloyl-camelliagenin A, or 22-O-(2Z)-hexenoyl-camelliagenin A as the aglycon. The pentasaccharide moiety linked to C-3 of the aglycon consists of D-glucuronic acid, L-rhamnose, D-glucose, and/or D-galactose. Their structures were elucidated by extensive NMR experiments including 1H-1H (COSY, 2D HOHAHA, NOESY) and 1H-13C (HMQC and HMBC) spectroscopy and chemical evidence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Carbohydrate Sequence
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Saponins / isolation & purification*
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Saponins / pharmacology
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Stereoisomerism
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Trees*
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Saponins
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Triterpenes