Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

Mol Cell Probes. 1999 Jun;13(3):199-202. doi: 10.1006/mcpr.1999.0237.

Abstract

The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Artificial, Yeast
  • Chromosomes, Human, Pair 17*
  • Contig Mapping*
  • DNA-Binding Proteins / genetics*
  • Forkhead Transcription Factors
  • Humans
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • Forkhead Transcription Factors
  • Transcription Factors
  • Whn protein

Grants and funding