Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase

Bioorg Med Chem Lett. 1999 May 17;9(10):1365-70. doi: 10.1016/s0960-894x(99)00206-1.

Abstract

Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives*
  • Adenosine Monophosphate / chemistry
  • Adenosine Monophosphate / pharmacology
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Drug Design
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Humans
  • Methionine / analogs & derivatives*
  • Methionine / chemistry
  • Methionine / pharmacology
  • Methionine-tRNA Ligase / antagonists & inhibitors*
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / enzymology
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / enzymology

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Enzyme Inhibitors
  • methioninyl adenylate
  • Adenosine Monophosphate
  • Methionine
  • Methionine-tRNA Ligase