Effect of sevoflurane concentration on inhalation induction of anaesthesia in the elderly

Br J Anaesth. 1999 Jan;82(1):20-4. doi: 10.1093/bja/82.1.20.

Abstract

We have conducted a randomized, double-blind comparison of 4% and 8% sevoflurane for induction of anaesthesia in unpremedicated patients aged more than 60 yr. Sevoflurane was inhaled in 50% nitrous oxide using a vital capacity breath technique, and mean, systolic and diastolic arterial pressures and heart rate were monitored continuously using a Finapres cuff. In the 8% sevoflurane group, time to successful laryngeal mask insertion was significantly shorter (mean 168 (SD 34) s vs 226 (62) s; P < 0.01) and achieved more often at the first attempt than in the 4% sevoflurane group. Arterial pressures were lower in the 8% group, but this was not significant. No patient had apnoea lasting longer than 1 min. A total of 69% of patients described induction as pleasant and 85% would choose to have it again. We conclude that compared with 8% sevoflurane, the use of 4% sevoflurane in the elderly resulted in greater cardiovascular stability but at the cost of prolonged and occasionally unsuccessful induction.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anesthesia, Inhalation / methods
  • Anesthetics, Inhalation / administration & dosage*
  • Anesthetics, Inhalation / pharmacology
  • Blood Pressure / drug effects
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Methyl Ethers / administration & dosage*
  • Methyl Ethers / pharmacology
  • Middle Aged
  • Patient Satisfaction
  • Sevoflurane
  • Time Factors

Substances

  • Anesthetics, Inhalation
  • Methyl Ethers
  • Sevoflurane