Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses

Curr Opin Immunol. 1999 Apr;11(2):223-8. doi: 10.1016/s0952-7915(99)80038-7.

Abstract

Many recent studies have demonstrated the flexibility of epitope recognition by the immune system. This can be explored using a particular type of combinatorial peptide library, termed as 'convergent', consisting essentially of closely related molecular species; from this a fuzzy set can be constructed, which comprises several variants of a peptide that would act in synchrony to represent a model antigen and its recognition by the immune system.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / immunology*
  • Epitopes
  • Humans
  • Molecular Sequence Data
  • Peptide Library*
  • Peptides / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Antigens
  • Epitopes
  • Peptide Library
  • Peptides