Abstract
Early efforts to place the first cloned mammalian PIK-related kinase, FRAP, into a conventional membrane to nuclear pathway met with little success. More recent data suggest that members of the family of PIK-related kinases act as intracellular sensors that govern radial and horizontal pathways. These pathways can impinge upon classical membrane to nuclear pathways, as well as components of the cell-cycle machinery.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Carrier Proteins*
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Cell Cycle / physiology
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Cell Nucleus / physiology
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Humans
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Immunophilins / metabolism*
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Phosphatidylinositol 3-Kinases / metabolism
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Phosphotransferases (Alcohol Group Acceptor)*
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Signal Transduction*
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Sirolimus / pharmacology
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TOR Serine-Threonine Kinases
Substances
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Anti-Bacterial Agents
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Carrier Proteins
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Phosphotransferases (Alcohol Group Acceptor)
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MTOR protein, human
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TOR Serine-Threonine Kinases
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Immunophilins
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Sirolimus