Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells

Planta Med. 1999 Apr;65(3):227-9. doi: 10.1055/s-1999-13985.

Abstract

Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhibit adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metalloproteinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whereas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Carcinoma, Lewis Lung / pathology*
  • Cell Division / drug effects*
  • Gallic Acid / analogs & derivatives*
  • Gallic Acid / pharmacology
  • Glucose / analogs & derivatives*
  • Glucose / pharmacology
  • Hexoses / pharmacology*
  • Mice
  • Neoplasm Invasiveness*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Hexoses
  • Gallic Acid
  • 1,2,3,6-tetragalloylglucose
  • Glucose
  • hamamelitannin