Abstract
Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhibit adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metalloproteinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whereas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Carcinoma, Lewis Lung / pathology*
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Cell Division / drug effects*
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Gallic Acid / analogs & derivatives*
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Gallic Acid / pharmacology
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Glucose / analogs & derivatives*
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Glucose / pharmacology
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Hexoses / pharmacology*
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Mice
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Neoplasm Invasiveness*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Hexoses
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Gallic Acid
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1,2,3,6-tetragalloylglucose
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Glucose
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hamamelitannin