The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis

Neurology. 1999 Apr 22;52(7):1492-4. doi: 10.1212/wnl.52.7.1492.

Abstract

In 13 subjects with ALS, we studied the safety and pharmacokinetic properties of Procysteine, a cysteine prodrug that increases levels of intracellular glutathione. We found that oral administration of Procysteine was safe. Procysteine enters CSF after both IV and oral dosing and accumulates to significant levels in CSF. We also observed that CSF levels of glutathione fall dramatically with aging.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Adult
  • Amyotrophic Lateral Sclerosis / cerebrospinal fluid
  • Amyotrophic Lateral Sclerosis / drug therapy*
  • Glutathione / cerebrospinal fluid
  • Humans
  • Infusions, Intravenous
  • Middle Aged
  • Pyrrolidonecarboxylic Acid
  • Thiazoles / administration & dosage
  • Thiazoles / pharmacokinetics*
  • Thiazoles / pharmacology*
  • Thiazolidines

Substances

  • Thiazoles
  • Thiazolidines
  • Glutathione
  • Pyrrolidonecarboxylic Acid
  • 2-oxothiazolidine-4-carboxylic acid