Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists

I S Lee; K Y Jung; S R Oh; S H Park; K S Ahn; H K Lee

doi:10.1248/bpb.22.265

Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists

Biol Pharm Bull. 1999 Mar;22(3):265-7. doi: 10.1248/bpb.22.265.

Authors

I S Lee¹, K Y Jung, S R Oh, S H Park, K S Ahn, H K Lee

Affiliation

¹ Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon.

PMID: 10220282
DOI: 10.1248/bpb.22.265

Abstract

We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1x10(-6) M) in this study.

MeSH terms

Biphenyl Compounds / chemistry
Cyclooctanes*
Esterification
Hydroxylation
Lignans / chemistry*
Lignans / pharmacology
Plants, Medicinal / chemistry*
Platelet Activating Factor / antagonists & inhibitors*
Polycyclic Compounds / chemistry*
Polycyclic Compounds / pharmacology
Structure-Activity Relationship

Substances

Biphenyl Compounds
Cyclooctanes
Lignans
Platelet Activating Factor
Polycyclic Compounds
schizandrin B
schizandrin