Is gliadin mispresented to the immune system in coeliac disease? A hypothesis

QJM. 1999 Feb;92(2):119-22. doi: 10.1093/qjmed/92.2.119.

Abstract

The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigen-Presenting Cells / immunology*
  • Antigens, CD / immunology
  • Celiac Disease / immunology*
  • Genes, MHC Class I / immunology
  • Gliadin / immunology*
  • Gliadin / metabolism
  • Humans
  • Immune System / immunology
  • T-Lymphocytes / immunology*
  • Transglutaminases / immunology

Substances

  • Antigens, CD
  • Gliadin
  • Transglutaminases