[The effect of compounds with antioxidant properties on thrombocyte functional activity]

A A Spasov; O V Ostrovskiĭ; I V Ivakhnenko; V A Kosolapov; V A Anisimova

[The effect of compounds with antioxidant properties on thrombocyte functional activity]

Eksp Klin Farmakol. 1999 Jan-Feb;62(1):38-40.

[Article in Russian]

Authors

A A Spasov¹, O V Ostrovskiĭ, I V Ivakhnenko, V A Kosolapov, V A Anisimova

Affiliation

¹ Department of Pharmacology, Volgograd Medical Academy, Russia.

PMID: 10198764

Abstract

The effect of antioxidant compounds ionol and mexidol and the new phenol derivative N9-imidazo-(1,2 alpha)-benzymidazol (PY-185) on the functional activity of blood platelets was studied. All the compounds under study effectively inhibited blood platelet aggregation both in vitro and in administration into rats, a result of which the blood thrombogenic potential reduced.

Publication types

Comparative Study

MeSH terms

Animals
Antioxidants / pharmacology*
Benzimidazoles / pharmacology
Butylated Hydroxytoluene / pharmacology
Humans
Imidazoles / pharmacology
Picolines / pharmacology
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / pharmacology*
Platelet Count / drug effects
Rabbits
Rats
Thrombelastography

Substances

Antioxidants
Benzimidazoles
Imidazoles
N(9)-imidazo-(1,2)-benzimidazol
Picolines
Platelet Aggregation Inhibitors
Butylated Hydroxytoluene
emoxypine succinate