Stereoselective synthesis of novel cyclopropyl analogues of known cysteine protease inhibitors

J S Kumar; S Roy; A Datta

doi:10.1016/s0960-894x(99)00029-3

Stereoselective synthesis of novel cyclopropyl analogues of known cysteine protease inhibitors

Bioorg Med Chem Lett. 1999 Feb 22;9(4):513-4. doi: 10.1016/s0960-894x(99)00029-3.

Authors

J S Kumar¹, S Roy, A Datta

Affiliation

¹ Organic III, Indian Institute of Chemical Technology, Hyderabad.

PMID: 10098652
DOI: 10.1016/s0960-894x(99)00029-3

Abstract

Efficient synthesis of two novel analogues of some known protease inhibitors, via the isosteric replacement of oxirane/aziridine moiety of the parent compounds by cyclopropane ring, is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aziridines / chemistry
Cysteine Proteinase Inhibitors / chemical synthesis
Cysteine Proteinase Inhibitors / chemistry*
Ethylene Oxide / chemistry
Stereoisomerism
Structure-Activity Relationship

Substances

Aziridines
Cysteine Proteinase Inhibitors
aziridine
Ethylene Oxide